Heyrim Cho
Ph.D, Postdoc at University of Maryland, College Park

 

I am currently a Brin postdoc fellow at University of Maryland, College Park, working with Doron Levy on modeling and simulation of tumor growth and drug resistance. I received my Ph.D. from the Division of Applied Math at Brown University, working with George Em Karniadakis in the CRUNCH group.
My research interest is in mathematical and computational biology, uncertainty quantification, and scientific computing. I have been developing numerical methods for probability density functions (PDFs) and studied various systems with this approach from stochastic dynamical systems to nonlinear PDEs that generates random shocks. I am also working on modeling dynamics of cancer growth and drug resistance in the purpose of optimizing anticancer therapies.
I received my B.S. in Applied mathematics and M.S.in Mathematics from KAIST (Korea Advanced Institute on Science and Technology), worked with Professor Chang-Ock Lee.

Research Interests

  Mathematical and Computational Biology, Cancer modeling
  Stochastic modeling and Uncertainty Quantification 
  Computational methods for high-dimensional stochastic systems 
  Multi-scale modeling and simulations 
  Numerical PDE and High-performance computing 

Preprint

  E. Kim, R. Schenck, J. West, W. Cross, V. Harris, J. McKenna, H. Cho, E. Coker, S. L-Kramer, K. Tsai, E. Flores, C. D. Gatenbee ‘Targeting the Untargetable: Predicting Pramlintide Resistance Using a Neural Network Based Cellular Automata’ bioRxiv, https://doi.org/10.1101/211383
  H. Cho, D. Levy, 'The Impact of Competition Between Cancer Cells and Healthy Cells on Optimal Drug Delivery', https://arxiv.org/abs/1806.07477, submitted, 2018

Publications

  H. Cho, D. Levy, 'Modeling continuous levels of resistance to multidrug therapy in cancer', Appl Math Model., 2018 [arXiv]
  H. Cho, K. Ayers, L. DePillis, Y-H. Kuo, J. Park, A. Radunskaya, R. Rockne, ‘Modeling acute myeloid leukemia in a continuum of differentiation states’, Lett.Biomath., 2018
  H. Cho, D. Levy, 'Modeling the chemotherapy-induced selection of drug-resistant traits during tumor growth', J. Theor. Biol. 436(7), 2018
  H. Cho, H. Elman, ‘An adaptive reduced basis collocation method based on PCM for anisotropic stochastic PDEs’, Int. J. Uncertain. Quantif. 8(3), 2018 [arXiv]
  H. Cho, D. Levy, 'Modeling the dynamics of heterogeneity of solid tumors in response to chemotherapy', Bull. Math. Bio. 79(12), 2017
  H. Cho, D. Venturi, G. E. Karniadakis, ‘Numerical methods for high-dimensional probability density function equations', J. Comput. Phys. 305, 2016
  H. Cho, X. Yang, D. Venturi, G. E. Karniadakis, 'Algorithms for propagating uncertainty across heterogeneous domains', SIAM J. Sci. Comput. 37(6), 2015
  H. Cho,  D. Venturi, G. E. Karniadakis, ‘Statistical analysis and simulation of random shocks in Burgers turbulence’, Proc. R. Soc. A, 470(2171), 2014.
  H. Cho, D. Venturi, G. E. Karniadakis, ‘Karhunen-Loeve expansion for multi-correlated stochastic processes’, Probabilistic Eng. Mech., 2013  
  H. Cho, D. Venturi, G. E. Karniadakis, ‘Adaptive discontinuous Galerkin method for response-excitation PDF equations’, SIAM J. Sci. Comput. 2013 
  D. Venturi, T. P. Sapis, H. Cho, G. E. Karniadakis, ‘A computable evolution equation for the joint response-excitation probability density function of stochastic dynamical systems', Proc. R. Soc. A 2012 

Book Chapters

  H. Cho, D. Venturi, G. E. Karniadakis, ‘Numerical methods for high-dimensional kinetic equations’, SEMA SIMAI Springer Series, Uncertainty Quantification for Hyperbolic and Kinetic Equations, 2017
  D. Venturi, H. Cho, G. E. Karniadakis, ‘Mori-Zwanzig approach to uncertainty quantification’, Springer, Handbook on Uncertainty Quantification, 2017

Theses

  H. Cho, ‘High-Dimensional Response-Excitation PDF Methods for Uncertainty Quantification and Stochastic Modeling’, Brown University (Ph.D. 2015), Advisor: Professor G. E. Karniadakis. PDF
  H. Cho, ‘Implementation of Dual Iterative Substructuring methods on a Parallel computer’, KAIST (MS 2009), Advisor: Professor C.-O., Lee. PDF

Invited talks in conferences   

  Check out some of my talks! -> SIAM-UQ12, SIAM-UQ14
Check out some of my posters! -> IMO16, IMA18

  · 'Modeling continuous levels of cell states in cancer development and drug resistance’, JMM2019, Baltimore MD, 2019
  · 'Modeling continuous levels of cell differentiation in acute myeloid leukemia (AML)’, SIAM-LS18, MN, 2018
  · 'Modeling continuous levels of resistance to combination therapy in cancer’, SMB2018, Sydney, 2018
  · 'Modeling continuous levels of resistance to combination therapy in cancer’, Division of Math Oncology, Beckman Research Institute, 2018
  · 'Numerical methods for uncertainty quantification - from noise parameterization to efficient simulation of parameterized stochastic PDE’, Applied Mathematics Colloquium, UMBC, 2017
  · 'High-dimensional stochastic simulation and dimension reduction techniques’, MathSci Seminar, KAIST, 2017
  · 'Modeling chemotherapy-induced selection of drug-resistant traits during tumor growth’, Math. Meth. in Bio. Medicine, WPI, 2017
  · 'Modeling the dynamics of heterogeneity in response to chemotherapy’, SMB2017, Utah, 2017
  · 'Uncertainty propagation across distinct PDF and stochastic spectral systems', (SIAM-UQ16), EPFL, 2016
  · 'Uncertainty quantification based on the response-excitation PDF and reduced order PDF by using Mori-Zwanzig PDF approach’, (SIAM-CSE15), Salt Lake City UT, 2015
  · 'High-dimensional response-excitation PDF method : separated representation and ANOVA approximation',   International Conference on Spectral and High Order Methods (ICOSAHOM 2014), Salt Lake City UT, 2014 
  · 'Karhunen-Loeve expansion for multi-correlated stochastic processes'  SIAM-UQ14, Savannah GA, 2014 
  · 'Study of the stochastic inviscid Burgers equation with the joint response-excitation PDF equation',  4th International congress on Computational Engineering and Sciences (FEMTEC 2013), Las Vegas NV, 2013  
  · 'Numerical methods for high-dimensional response-excitation PDF equations',  14th International conference on Approximation Theory (AT14), San Antonio TX, 2013 
  · 'Spectral/hp element and discontinuous Galerkin methods for response-excitation PDF equations',   SIAM-CSE13, Boston (MA), 2013.
  · 'A new approach to UQ based on the joint excitation-response PDF: Theory and simulation',  SIAM-UQ12, Raleigh NC, 2012

 

 


Follow your bliss and the universe will open doors for you where there were only walls.
     ― Joseph Campbell   :)